%0 Journal Article
%T ENZYMOLOGY OF MICROBIAL DEGRADATION OF ORGANOPHOSPHATE CHEMICALS<br>微生物降解有机磷类毒剂的酶学研究进展*
%A FU Guo-Ping
%A CUI Zhong-Li
%A WU Xu-Ping
%A XU Wei
%A LI Shun-Peng
%A <br>傅国平
%A 崔中利
%A 吴旭平
%A 徐玮
%A 李顺鹏
%J 微生物学通报
%D 2004
%I 
%X Organophosphate chemicals are widely used as agricultural pesticides and war reagents, their biodegradation is emphasized on the theoretical and practical aspects. Organophosphate hydrolases play important roles in the biodegradation of organophosphate chemicals. Great advancement was achieved recently in the determination of crystal structure and catalytic mechanisms of the hydrolase. This paper reviewed the research progresses in the enzymology, protein structure, catalytic mechanisms and application of the organophosphate hydrolase, and predicted the future research in this field.
%K Organophosphate chemicals
%K Organophosphate hydrolase
%K Protein structure
%K Catalytic mechanism
%K Rational evolution<br>有机磷毒剂
%K 有机磷水解酶
%K 高级结构
%K 催化机制
%K 定向进化
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=78024727B5F4EF6AA9CA8E605B5FC464&aid=FD5B0E03E535706B&yid=D0E58B75BFD8E51C&vid=4AD960B5AD2D111A&iid=0B39A22176CE99FB&sid=09E495F616948E78&eid=475189FCB44F11F6&journal_id=0253-2654&journal_name=微生物学通报&referenced_num=4&reference_num=14