%0 Journal Article
%T Research on the Isolation, Cell Toxicity and Antifungal Activity Against Candida albicans of Novel Decarboxylated FR-008/Candicidin Derivative CS103<br>基因工程FR-008/杀念菌素脱羧衍生物CS103的分离提取及毒性和抗白色念珠菌活性研究
%A MAO Xiang-Zhao
%A TAO Xin-Yi
%A YANG Liang
%A SHEN Ya-Ling
%A WEI Dong-Zhi
%A DENG Zi-Xin
%A <br>毛相朝
%A 陶欣艺
%A 杨 亮
%A 沈亚领
%A 魏东芝
%A 邓子新
%J 微生物学通报
%D 2009
%I 
%X Based on founding the methods for isolation and purification of the novel decarboxylated FR-008/Candicidin derivative CS103, we obtained enough samples for testing from the culture mycelia of the mutant of Streptomyces FR-008. Through comparing the cell toxicities on Human Embryonic Kidney Cells 293, haemolytic activities on human erythrocytes and antifungal activities on C. albicans, we found that the toxicity of decarboxylated FR-008/Candicidin derivative CS103 had been lower than FR-008/Candicidin and Amphoteicin B, while it still had high antifungal activity on C. albicans.
%K FR-008/Candicidin
%K Novel decarboxylated derivative
%K Amphoteicin B
%K Toxicities
%K Antifungal activities<br>FR-008/杀念菌素
%K 脱羧衍生物CS103
%K 两性霉素B
%K 毒性
%K 抗真菌活性
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=78024727B5F4EF6AA9CA8E605B5FC464&aid=04FE86E3579CF75DD1F9DA2C40392B77&yid=DE12191FBD62783C&vid=933658645952ED9F&iid=59906B3B2830C2C5&sid=A477487C019ACAC8&eid=F393F687E70F258D&journal_id=0253-2654&journal_name=微生物学通报&referenced_num=0&reference_num=0