%0 Journal Article
%T Induction of Heme Oxygenase-1, Biliverdin Reductase and H-Ferritin in Lung Macrophage in Smokers with Primary Spontaneous Pneumothorax: Role of HIF-1¦Á
%A Delphine Goven
%A Anne Boutten
%A V¨¦ronique Le£¿on-Malas
%A Jo£¿lle Marchal-Somm¨¦
%A Paul Soler
%A Jorge Boczkowski
%A Marcel Bonay
%J PLOS ONE
%D 2012
%I Public Library of Science (PLoS)
%R 10.1371/journal.pone.0010886
%X Few data concern the pathophysiology of primary spontaneous pneumothorax (PSP), which is associated with alveolar hypoxia/reoxygenation. This study tested the hypothesis that PSP is associated with oxidative stress in lung macrophages. We analysed expression of the oxidative stress marker 4-HNE; the antioxidant and anti-inflammatory proteins heme oxygenase-1 (HO-1), biliverdin reductase (BVR) and heavy chain of ferritin (H-ferritin); and the transcription factors controlling their expression Nrf2 and HIF-1¦Á, in lung samples from smoker and nonsmoker patients with PSP (PSP-S and PSP-NS), cigarette smoke being a risk factor of recurrence of the disease.
%U http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0010886