%0 Journal Article
%T Recent Advances on Reverse Genetics of Foot-and-mouth Disease Virus<br>口蹄疫病毒反向遗传学研究进展
%A BAI Xing-Wen
%A LI Ping-Hu
%A LIU Zai-Xin
%A LIU Xiang-Tao
%A XIE Qing-Ge
%A <br>白兴文
%A 李平花
%A 刘在新
%A 刘湘涛
%A 谢庆阁
%J 微生物学通报
%D 2009
%I 
%X Usage of reverse genetic techniques in the research area of the fundamental etiology of foot-and-mouth disease virus (FMDV), has resolved the issue about the function of viral gene of FMDV on genomic integer level. At present, a further recognition and apprehension for the molecular etiology of FMDV based on the development in reverse genetics was made. Combined with the research work in our labs, we reviewed international advances about the molecular pathogenic mechanism, the relationship between virulence and variation in the genomes, influencing factors for the viral replication, and the development of new-type gene vaccine of FMD in this article, and propose the potential research aspects in reverse genetics of FMDV in the future.
%K Foot-and-mouth disease virus
%K Reverse genetics
%K Infectious molecular clone<br>口蹄疫病毒
%K 反向遗传学
%K 感染性分子克隆
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=78024727B5F4EF6AA9CA8E605B5FC464&aid=A2915D2DE1DC94DCC448794B2C895FFC&yid=DE12191FBD62783C&vid=933658645952ED9F&iid=CA4FD0336C81A37A&sid=4558201B27BA2308&eid=5A61581155612631&journal_id=0253-2654&journal_name=微生物学通报&referenced_num=0&reference_num=0