%0 Journal Article
%T BREEDING OF SINGLE COMPONENT SAGAMICIN-PRODUCING STRAIN AND STUDIES ON FERMENTATION CONDITIONS<br>小诺霉素单组份菌种选育及发酵条件研究
%A YANG Li
%A LIU Yi-Fan
%A ZHOU Qing-Lian
%A WANG Fan-Ye
%A <br>杨丽
%A 刘亦凡
%A 周清莲
%A 王繁业
%J 微生物学通报
%D 2000
%I 
%X Micromonospora echinospora A-23 was screened through protoplast UV-ray, electrofasion regeneration, near ultraviolet light in presence of 8-methoxypsoralen, combined tratment of LiCl and UV-ray, etc, and isolated single colonies with natural selection. A high and stable sagamictu-producing strain MS-116 was obtained through several-decade generations of the treatment. The main component content increased to over 85%. The culture medium and the effective factors on fermentation was also studied. Trial-production by 30 ton-fermentor indicated that the strain is high and stable is high and stable sapamicin-producing strain for industrial production.
%K Sagamicin
%K Single component
%K Mutants
%K Fermentation<br>小诺霉素
%K 单组份
%K 突变株
%K 发酵
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=78024727B5F4EF6AA9CA8E605B5FC464&aid=BCC7F3B43C2EDAE6&yid=9806D0D4EAA9BED3&vid=DB817633AA4F79B9&iid=E158A972A605785F&sid=4290346F7268639E&eid=89AC6B0ADBEA2741&journal_id=0253-2654&journal_name=微生物学通报&referenced_num=3&reference_num=6