%0 Journal Article
%T Effect of Shear Rate on the Aggregation Behavior of Self-Aggregated Glycyrrhizin Micelles by MesoDyn<br>剪切作用对甘草皂苷胶束聚集形态影响的介观模拟研究
%A Wang Yuguang
%A Shi Xinyuan
%A Qiao Yanjiang
%A <br>王宇光
%A 史新元
%A 乔延江
%J 世界科学技术-中医药现代化
%D 2012
%I 
%X MesoDyn has been carried out to elaborate the micellar properties of natural surfactant glycyrrhizin which is frequently used in traditional Chinese medicine (TCM). The effect of shear rate on the aggregation behavior of glycyrrhizin has been investigated. The results showed that the critical micelle concentration of glycyrrhizin increased with the addition of shear rate. And the glycyrrhizin aggregation transformed from spherical micelle to cylindrical micelle as the increase of shear rate. Furthermore, the aggregation behavior of the as-formed micelle was not stable to the change of shear rate. Removal of shear rate was unable to recover the micelle completely in the changing process of shear rate. The simulation results provide mesoscopic information for the solubilization of poorly water-soluble drug, and at the same time provide guidance for high efficient experiments.
%K Glycyrrhizin
%K mesoscopic simulation
%K solubilization
%K aggregation behavior
%K shear rate<br>甘草皂苷
%K 介观模拟
%K 增溶
%K 聚集形态
%K 剪切
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=A9DB1C13C87CE289EA38239A9433C9DC&cid=B5F35A1FC27C1FF7&jid=44257A35316DB0727BA6BC707B9EDAAB&aid=790A9358A1C1D655B50DC2A1AF3EA4EF&yid=99E9153A83D4CB11&vid=F3583C8E78166B9E&iid=CA4FD0336C81A37A&sid=B4942BBE94415B36&eid=C698B4DF5D56174F&journal_id=1674-3849&journal_name=世界科学技术-中医药现代化&referenced_num=0&reference_num=0