%0 Journal Article
%T Progress in Pharmacokinetic Researches of Baicalein<br>黄芩素药代动力学研究进展
%A Zhang Wenyu
%A Dai Jianye
%A Sun Shujun
%A Cao Huijuan
%A Zheng Ningning
%A Fang Junwei
%A Gou Xiaojun
%A Liu Chenghai
%A Liu Ping
%A Zhang Yongyu
%A <br>王文玉
%A 戴建业
%A 孙淑军
%A 曹慧娟
%A 郑宁宁
%A 房军伟
%A 苟小军
%A 刘成海
%A 刘平
%A 张永煜
%J 世界科学技术-中医药现代化
%D 2011
%I 
%X Scutellaria baicalensis Georgi, included in Chinese Pharmacopoeia, has been long used as a traditional Chinese medicinal material, which contains many kinds of flavonoids compounds, and baicalein is one of the main active components. Here, we present the recent reviews of pharmacokinetics of baicalein in vivo, and find out that:it has good absorption in gastrointestinal tract and distributes mainly in liver, kidney, lung and other vital organs and tissues; the main metabolites of baicalein in rat are the compounds of baicalein with glucuronic acid, which can be transported to gut lumen by bile and intestine mucous membrane, and can be reabsorbed. The concentration of the unchanged drug in plasma is very low after oral administration of baicalein. At present, the research on pharmacokinetics of baicalein is mainly achieved indirectly by determining baicalin, which suggests that baicalein may substitute for baicalin in oral preparation.
%K Baicalein
%K pharmacokinetics
%K flavonoid<br>黄芩素
%K 药代动力学
%K 黄酮
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=A9DB1C13C87CE289EA38239A9433C9DC&cid=B5F35A1FC27C1FF7&jid=44257A35316DB0727BA6BC707B9EDAAB&aid=656E32E02735604BFEC5489990FCBF95&yid=9377ED8094509821&vid=FC0714F8D2EB605D&iid=B31275AF3241DB2D&sid=5839F1C61E1C000D&eid=5D5B6851F9BAEE73&journal_id=1674-3849&journal_name=世界科学技术-中医药现代化&referenced_num=0&reference_num=0