%0 Journal Article
%T Zhen-Nao-Ning Capsules Ameliorate Migraine via Regulating Monoamine Neurotransmitters<br>镇脑宁胶囊治疗偏头痛作用研究
%A Dong Shifen
%A Chen Hong
%A Chai Yujing
%A Yu Xiumei
%A Sun Jianning
%A <br>董世芬
%A 陈红
%A 柴玉晶
%A 于秀梅
%A 孙建宁
%J 世界科学技术-中医药现代化
%D 2012
%I 
%X This study was aimed to evaluate the effect of Zhen -Nao -Ning capsules on experimental migraine model mice. The experimental migraine model mice were induced by injecting reserpine injection and blood clots. The pain threshold was determined by hot -plate method and monoamine neurotransmitters including norepinephrine (NE), dopamine (DA), 5-hydroxytryptamine (5-HT) and 5-hydroxy indole acetic (5-HIAA) which were measured by fluorescence spectrophotometry method. The symptom of pain among animal models can be relieved in different degrees by the treatment of Zhen -Nao -Ning capsule at the dosage of 200-800 mg/kg. The pain threshold can be increased 27% after treatment of Zhen -Nao -Ning capsule at the dosage of 800 mg/kg. And contents of NE, DA, 5-HT and 5-HIAA were increased 34%, 33%, 20%, and 30%, respectively. The results indicated that Zhen-Nao-Ning capsule can ameliorate migraine via regulating monoamine neurotransmitters.
%K Zhen-Nao-Ning capsule
%K migraine
%K monoamine neurotransmitters<br>镇脑宁胶囊
%K 偏头痛
%K 单胺类神经递质
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=A9DB1C13C87CE289EA38239A9433C9DC&cid=B5F35A1FC27C1FF7&jid=44257A35316DB0727BA6BC707B9EDAAB&aid=08F5EC0AA8616491B92D343994AF5C70&yid=99E9153A83D4CB11&vid=F3583C8E78166B9E&iid=94C357A881DFC066&sid=5ACAEB88D41E54A7&eid=84307FA918B9F395&journal_id=1674-3849&journal_name=世界科学技术-中医药现代化&referenced_num=0&reference_num=0