%0 Journal Article
%T Whole-Body Systems Biology Based on Functional Metagenomics-- New Opportunity for the Modernization of Traditional Chinese Medicine<br>基于功能元基因组学的人体系统生物学新方法：中医药现代化的契机
%A Zhang Xu
%A Zhao Yufeng
%A Hu Yiyang
%A Liu Ping
%A Zhao Liping
%A <br>张 旭
%A 赵宇峰
%A 胡义扬
%A 刘 平
%A 赵立平
%J 世界科学技术-中医药现代化
%D 2011
%I 
%X Traditional Chinese medicine(TCM) is a medical system with its own theoretical framework focusing on functions at the whole-body level.TCM has accumulated abundant clinical experiences.However,TCM approaches are empirical and the signs it reads can not be communicated in molecular language with modern medicine.Whole-body systems biology regards human body as a "superorganism",which is consisted of cells of both human and symbiotic microorganisms.Taking advantage of "-omic" technologies,biological information in urine,fecal and blood samples can be profiled as emergent functions of the complex human system for the understanding of its dynamics in disease and health.This top-down systems biology emphasizes the function of gut microbiota in human health.The whole-body systems biology not only assesses human health with molecular-based methods,but also has the holistic approach as TCM.Thus,this method can be served as a bridge between TCM and the western medical science.This paper summarized concepts,methodologies,clinical application and advantage of whole-body systems biology.Hence,functional metagenomics has been proposed as a new research strategy for the modernization of TCM.
%K 人体系统生物学
%K 中医药现代化
%K 肠道菌群
%K 功能元基因组学
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=A9DB1C13C87CE289EA38239A9433C9DC&cid=B5F35A1FC27C1FF7&jid=44257A35316DB0727BA6BC707B9EDAAB&aid=B8035D61C1BAF40F8F20CF5644BED19D&yid=9377ED8094509821&vid=FC0714F8D2EB605D&iid=0B39A22176CE99FB&sid=974CBB04624305A1&eid=D2742EEE6F4DF8FE&journal_id=1674-3849&journal_name=世界科学技术-中医药现代化&referenced_num=0&reference_num=0