%0 Journal Article
%T A Randomised Trial to Compare the Safety, Tolerability and Efficacy of Three Drug Combinations for Intermittent Preventive Treatment in Children
%A Kalifa Bojang
%A Francis Akor
%A Ousman Bittaye
%A David Conway
%A Christian Bottomley
%A Paul Milligan
%A Brian Greenwood
%J PLOS ONE
%D 2012
%I Public Library of Science (PLoS)
%R 10.1371/journal.pone.0011225
%X Results from trials of intermittent preventive treatment (IPT) in infants and children have shown that IPT provides significant protection against clinical malaria. Sulfadoxine-pyrimethamine (SP) given alone or in combination with other drugs has been used for most IPT programmes. However, SP resistance is increasing in many parts of Africa. Thus, we have investigated whether SP plus AQ, SP plus piperaquine (PQ) and dihydroartemisinin (DHA) plus PQ might be equally safe and effective when used for IPT in children in an area of seasonal transmission.
%U http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0011225