%0 Journal Article
%T Application of Pharmacophore Technique in the Study of Effective Substance of Chinese Medicinals<br>药效团技术在中药药效成分研究中的应用
%A Wang Xing
%A Zhang Yanling
%A Qiao Yanjiang
%A <br>王星
%A 张燕玲
%A 乔延江
%J 世界科学技术-中医药现代化
%D 2012
%I 
%X The effective substance of Chinese medicinals has been a focus of traditional Chinese medicine (TCM) studies for long time. With the application of pharmacophore-based 3D structure database searching in the discovery and optimization of lead compounds for drug design, the pharmacophore technology has gradually caught attention in modern TCM studies in recent years. In this paper, the progress of pharmacophore methods was used. The application of pharmacophore methods in the Active Clusters of Traditional Chinese Medicine(AC-TCM) identification, targets searching, action of TCM on metabolic enzymes and the study in the properties of TCM was reviewed. Also problems, strategy and prospect of pharmacophore in the study of TCM were discussed.
%K Pharmacophore
%K identification of active clusters in Chinese medicine
%K target searching
%K application<br>药效团
%K 中药有效成分辨识
%K 靶标搜寻
%K 应用
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=A9DB1C13C87CE289EA38239A9433C9DC&cid=B5F35A1FC27C1FF7&jid=44257A35316DB0727BA6BC707B9EDAAB&aid=AA4D21AF3759F1D4C0EA7C59DF06D335&yid=99E9153A83D4CB11&vid=F3583C8E78166B9E&iid=E158A972A605785F&sid=1B1F9B96EF7F53E5&eid=F654D651B5009E39&journal_id=1674-3849&journal_name=世界科学技术-中医药现代化&referenced_num=0&reference_num=0