%0 Journal Article
%T Pharmacokinetics of Isofraxidin in Extracellular Fluids of Striatum in Rats Using Microdialysis-UPLC Method<br>基于微透析-UPLC技术的异嗪皮啶 大鼠脑纹状体细胞外液药动学研究
%A Liu Shumin
%A Tang Bo
%A Lu Fang
%A Fan Zhenqun
%A Zhou Shihui
%A <br>刘树民
%A 唐 波
%A 卢 芳
%A 范振群
%A 周世慧
%J 世界科学技术-中医药现代化
%D 2012
%I 
%X This study was aimed to observe the pharmacokinetic characteristics of isofraxidin in extracellular fluids of striatum in rats after oral administration of isofraxidin.Microdialysis and UPLC-MS analytical technology were employed in the study to detect the concentration of isofraxidin in microdialysis dialysate of extracellular fluids of striatum in rats,within 60 min after a single oral administration,with isofraxidin of 10 mg·kg-1 and 20 mg·kg-1,respectively.The results were revised by relative recovery in vivo.The pharmacokinetic parameters were calculated through non-compartment model method with software of WINONLIN 6.1 program.Main pharmacokinetic parameters of isofraxidin in extracellular fluids of striatum in rats after a single oral administration of isofraxidin at 10 mg·kg-1 and 20 mg·kg-1 were AUC0-∞(13973.88±1582.984) and(28059.76±4207.66) ng·min·mL-1;t1/2(16.68±0.49) and(17.41±2.88) min;Cmax(498.87±64.36) and(899.81±133.22) ng·mL-1.The tmax of both two groups was 15 min.Both the Cmax and tmax were measured.It is concluded that isofraxidin quickly permeates the blood-brain barrier and reaches the striatum.The maximal concentration of isofraxidin is 15 min after oral administration.And then the concentration decreases at a faster rate.It shows a significant dose-dependent phenomenon of the concentration of isofraxidin in extracellular fluids of striatum in rats.
%K Acanthopanax senticosus
%K isofraxidin
%K microdialysis
%K UPLC-MS
%K Pharmacokinetics<br>刺五加
%K 异嗪皮啶
%K 微透析
%K 超高效液相色谱-质谱联用
%K 药动学
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=A9DB1C13C87CE289EA38239A9433C9DC&cid=B5F35A1FC27C1FF7&jid=44257A35316DB0727BA6BC707B9EDAAB&aid=790A9358A1C1D655FD2105842444BBE9&yid=99E9153A83D4CB11&vid=F3583C8E78166B9E&iid=CA4FD0336C81A37A&sid=379827DA4720AA2A&eid=004AE5CF627F0ACA&journal_id=1674-3849&journal_name=世界科学技术-中医药现代化&referenced_num=0&reference_num=0