%0 Journal Article
%T Effects of Tongluo-Jiunao Injection on Cerebral Ischemia-Reperfusion Injury Rats<br>通络救脑注射液对大鼠脑缺血再灌注损伤脑保护的IGF-1途径分析
%A Tang Yibo
%A Tang Huiling
%A Zhang Wei
%A Wang Runjun
%A Yan Yangyang
%A Xu Liwei
%A Li Pengtao
%A <br>汤轶波
%A 唐卉凌
%A 张 玮
%A 王润俊
%A 闫杨杨
%A 徐丽伟
%A 李澎涛
%J 世界科学技术-中医药现代化
%D 2011
%I 
%X This study aimed to investigate the protective effects of Tongluo-Jiunao injection (TLJN) on brain tissues of focal cerebral ischemia-reperfusion injury rats. Cerebral ischemia-reperfusion injury rat model was established by middle cerebral artery occlusion. All animal models were divided into four groups, which were sham, model, TLJN, and edaravone group. The brain infarct volume, concentration of IGF-1 in brain tissues and serum were detected at 24 h, 3 d, and 7 d after cerebral ischemia-reperfusion injury. The results showed that compared to the model group, the brain infarct volume of TLJN group was significantly reduced, and the expression of IGF-1 of cerebral cortex was upregulated in TLJN group. It is concluded that TLJN has significant protective effects on brain tissues in focal cerebral ischemia-reperfusion injury rat. And the IGF-1 may play an important role in the protective effects of brain tissues.
%K Tongluo-Jiunao injection
%K IGF-1
%K neuron<br>通络救脑注射液
%K IGF-1
%K 神经元
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=A9DB1C13C87CE289EA38239A9433C9DC&cid=B5F35A1FC27C1FF7&jid=44257A35316DB0727BA6BC707B9EDAAB&aid=656E32E02735604BCAEE86C2F5F03DC1&yid=9377ED8094509821&vid=FC0714F8D2EB605D&iid=38B194292C032A66&sid=8CE1095CD639AEF4&eid=4A2356A1257A12EB&journal_id=1674-3849&journal_name=世界科学技术-中医药现代化&referenced_num=0&reference_num=0