%0 Journal Article
%T Study on in Vitro Release and Transdermal Absorption of Sinomenine in Fengshi-Gutong Gel Plaster<br>风湿骨痛凝胶贴膏中青藤碱体外释放及透皮吸收研究
%A Du Shouying
%A Lu Yang
%A Ren Xiaohui
%A Chen Xiaolan
%A Gong Weihong
%A <br>杜守颖
%A 陆洋
%A 任晓慧
%A 陈晓兰
%A 龚卫红
%J 世界科学技术-中医药现代化
%D 2012
%I 
%X This study was aimed to evaluate the in vitro release and transdermal absorption of the sinomenine in Fengshi-Gutong gel plaster. Sinomenine was analyzed by HPLC. The in vitro release behavior of the preparation was investigated through the application of TP-5 intelligence penetration tester. And hairless abdominal skin was used in the transdermal absorption study. The results showed that the cumulative releasing percent of sinomenine in Fengshi-Gutong gel plaster was 97.76% within 12 h. And the release curve fitted the Weibull equation, ln (1/(1-Q)) = 1.4012lnt + 0.2326 (r = 0.9875). The cumulative transdermal absorption percent within 12 h was 44.86%. And the transdermal absorption process fitted the Weibull equation, ln (1/(1-Q)) = 0.2118lnt + 0.0737(r = 0.9874). It was concluded that results of in vitro release and transdermal absorption of sinomenine in Fengshi-Gutong gel plaster were favorable. Therefore, this preparation is worth further development.
%K Fengshi-Gutong gel plaster
%K sinomenine
%K in vitro release
%K transdermal absorption<br>风湿骨痛凝胶贴膏
%K 青藤碱
%K 体外释放
%K 透皮吸收
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=A9DB1C13C87CE289EA38239A9433C9DC&cid=B5F35A1FC27C1FF7&jid=44257A35316DB0727BA6BC707B9EDAAB&aid=0B63987600F2A39C90BC4DB476689FED&yid=99E9153A83D4CB11&vid=F3583C8E78166B9E&iid=38B194292C032A66&sid=1396DEC9DD671DC4&eid=03F4C4D3CD1EB259&journal_id=1674-3849&journal_name=世界科学技术-中医药现代化&referenced_num=0&reference_num=0