%0 Journal Article
%T Transforming Growth Factor Beta 2 and Heme Oxygenase 1 Genes Are Risk Factors for the Cerebral Malaria Syndrome in Angolan Children
%A Maria Ros¨¢rio Sambo
%A Maria Jesus Trovoada
%A Carla Benchimol
%A Vat¨²sia Quinhentos
%A L¨ªgia Gon£¿alves
%A Rute Velosa
%A Maria Isabel Marques
%A Nuno Sep¨²lveda
%A Taane G. Clark
%A Stefan Mustafa
%A Oswald Wagner
%A Ant¨®nio Coutinho
%A Carlos Penha-Gon£¿alves
%J PLOS ONE
%D 2012
%I Public Library of Science (PLoS)
%R 10.1371/journal.pone.0011141
%X Cerebral malaria (CM) represents a severe outcome of the Plasmodium falciparum infection. Recent genetic studies have correlated human genes with severe malaria susceptibility, but there is little data on genetic variants that increase the risk of developing specific malaria clinical complications. Nevertheless, susceptibility to experimental CM in the mouse has been linked to host genes including Transforming Growth Factor Beta 2 (TGFB2) and Heme oxygenase-1 (HMOX1). Here, we tested whether those genes were governing the risk of progressing to CM in patients with severe malaria syndromes.
%U http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0011141