%0 Journal Article
%T Mu-Opioid Receptors Transiently Activate the Akt-nNOS Pathway to Produce Sustained Potentiation of PKC-Mediated NMDAR-CaMKII Signaling
%A Pilar S¨¢nchez-Bl¨¢zquez
%A Mar¨ªa Rodr¨ªguez-Mu£¿oz
%A Javier Garz¨®n
%J PLOS ONE
%D 2012
%I Public Library of Science (PLoS)
%R 10.1371/journal.pone.0011278
%X In periaqueductal grey (PAG) matter, cross-talk between the Mu-opioid receptor (MOR) and the glutamate N-methyl-D-Aspartate receptor (NMDAR)-CaMKII pathway supports the development of analgesic tolerance to morphine. In neurons, histidine triad nucleotide binding protein 1 (HINT1) connects the regulators of G protein signaling RGSZ1 and RGSZ2 to the C terminus of the MOR. In response to morphine, this HINT1-RGSZ complex binds PKC¦Ã, and afterwards, the interplay between PKC¦Ã, Src and Gz/Gi proteins leads to sustained potentiation of NMDAR-mediated glutamate responses.
%U http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0011278