%0 Journal Article
%T Mitochondrial DNA Mutations Induce Mitochondrial Dysfunction, Apoptosis and Sarcopenia in Skeletal Muscle of Mitochondrial DNA Mutator Mice
%A Asimina Hiona
%A Alberto Sanz
%A Gregory C. Kujoth
%A Reinald Pamplona
%A Arnold Y. Seo
%A Tim Hofer
%A Shinichi Someya
%A Takuya Miyakawa
%A Chie Nakayama
%A Alejandro K. Samhan-Arias
%A Stephane Servais
%A Jamie L. Barger
%A Manuel Portero-Ot¨ªn
%A Masaru Tanokura
%A Tomas A. Prolla
%A Christiaan Leeuwenburgh
%J PLOS ONE
%D 2012
%I Public Library of Science (PLoS)
%R 10.1371/journal.pone.0011468
%X Aging results in a progressive loss of skeletal muscle, a condition known as sarcopenia. Mitochondrial DNA (mtDNA) mutations accumulate with aging in skeletal muscle and correlate with muscle loss, although no causal relationship has been established.
%U http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0011468