%0 Journal Article
%T Recent Progress in Cellular Traction Force Microscopy Inversion Methods<br>细胞牵引力显微镜反演方法研究进展
%A HUANG Jian-yong
%A DENG Hao
%A PENG Xiao-ling
%A LI Shan-shan
%A XIONG Chun-yang
%A FANG Jing
%A <br>黄建永
%A 邓昊
%A 彭小玲
%A 李姗姗
%A 熊春阳
%A 方竞
%J 实验力学
%D 2011
%I 
%X Physical and mechanical interaction between cell and extracellular matrix in a microenvironment involves a large number of complex signaling transduction pathways, so it plays a key role in mediating cellular behaviors and functions such as cell proliferation, differentiation, contraction, migration and apoptosis. It is very important, both physiologically and pathologically, to quantitatively characterizing single cell activities based upon cellular traction force microscopy (CTFM). The core of CTFM consists in how to retrieve cellular traction force field from the measured substrate deformation data. This paper presents first an introduction about the principle of CTFM, and then point out the pathological nature of cellular traction inversion. Accordingly, some well-developed traction force inversion algorithms are specifically introduced, including: boundary element method (DW method), traction reconstruction with point forces (TRPF method), cellular traction recovery method based on an integral Boussinesq solution, Fourier transform traction cytometry (FTTC method), and optimal filtering method in two-dimensional Fourier space.
%K cell
%K elastic substrate
%K traction force microscopy
%K digital image correlation
%K ill-posed inverse problem
%K regularization<br>细胞
%K 弹性基底
%K 牵引力显微镜
%K 数字图像相关
%K 病态反问题
%K 正则化
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=6E709DC38FA1D09A4B578DD0906875B5B44D4D294832BB8E&cid=5D344E2AD54D14F8&jid=49067A0A0D864088C06A84AACB51A5B2&aid=EB1EEE94DAF205C65280AF05BFA9AA10&yid=9377ED8094509821&vid=96C778EE049EE47D&iid=DF92D298D3FF1E6E&sid=FD6137FFCE59D193&eid=EB8E83807F36F05B&journal_id=1001-4888&journal_name=实验力学&referenced_num=0&reference_num=0