%0 Journal Article
%T Quantifying the Proteolytic Release of Extracellular Matrix-Sequestered VEGF with a Computational Model
%A Prakash Vempati
%A Feilim Mac Gabhann
%A Aleksander S. Popel
%J PLOS ONE
%D 2012
%I Public Library of Science (PLoS)
%R 10.1371/journal.pone.0011860
%X VEGF proteolysis by plasmin or matrix metalloproteinases (MMPs) is believed to play an important role in regulating vascular patterning in vivo by releasing VEGF from the extracellular matrix (ECM). However, a quantitative understanding of the kinetics of VEGF cleavage and the efficiency of cell-mediated VEGF release is currently lacking. To address these uncertainties, we develop a molecular-detailed quantitative model of VEGF proteolysis, used here in the context of an endothelial sprout.
%U http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0011860