%0 Journal Article
%T Epstein-Barr Virus Interferes with the Amplification of IFN¦Á Secretion by Activating Suppressor of Cytokine Signaling 3 in Primary Human Monocytes
%A Fran£¿ois Michaud
%A Fran£¿ois Coulombe
%A Eric Gaudreault
%A Carine Paquet-Bouchard
%A Marek Rola-Pleszczynski
%A Jean Gosselin
%J PLOS ONE
%D 2012
%I Public Library of Science (PLoS)
%R 10.1371/journal.pone.0011908
%X Epstein-Barr virus is recognized to cause lymphoproliferative disorders and is also associated with cancer. Evidence suggests that monocytes are likely to be involved in EBV pathogenesis, especially due to a number of cellular functions altered in EBV-infected monocytes, a process that may affect efficient host defense. Because type I interferons (IFNs) are crucial mediators of host defense against viruses, we investigated the effect of EBV infection on the IFN¦Á pathway in primary human monocytes.
%U http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0011908