%0 Journal Article
%T PDE8 Regulates Rapid Teff Cell Adhesion and Proliferation Independent of ICER
%A Amanda G. Vang
%A Shlomo Z. Ben-Sasson
%A Hongli Dong
%A Barbara Kream
%A Michael P. DeNinno
%A Michelle M. Claffey
%A William Housley
%A Robert B. Clark
%A Paul M. Epstein
%A Stefan Brocke
%J PLOS ONE
%D 2012
%I Public Library of Science (PLoS)
%R 10.1371/journal.pone.0012011
%X Abolishing the inhibitory signal of intracellular cAMP by phosphodiesterases (PDEs) is a prerequisite for effector T (Teff) cell function. While PDE4 plays a prominent role, its control of cAMP levels in Teff cells is not exclusive. T cell activation has been shown to induce PDE8, a PDE isoform with 40- to 100-fold greater affinity for cAMP than PDE4. Thus, we postulated that PDE8 is an important regulator of Teff cell functions.
%U http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0012011