%0 Journal Article
%T Emulsified Nanoparticles Containing Inactivated Influenza Virus and CpG Oligodeoxynucleotides Critically Influences the Host Immune Responses in Mice
%A Ming-Hsi Huang
%A Su-Chen Lin
%A Chia-Hsin Hsiao
%A Hsin-Ju Chao
%A Hung-Ren Yang
%A Chien-Chun Liao
%A Po-Wei Chuang
%A Huang-Pi Wu
%A Chiung-Yi Huang
%A Chih-Hsiang Leng
%A Shih-Jen Liu
%A Hsin-Wei Chen
%A Ai-Hsiang Chou
%A Alan Yung-Chih Hu
%A Pele Chong
%J PLOS ONE
%D 2012
%I Public Library of Science (PLoS)
%R 10.1371/journal.pone.0012279
%X Antigen sparing and cross-protective immunity are regarded as crucial in pandemic influenza vaccine development. Both targets can be achieved by adjuvantation strategy to elicit a robust and broadened immune response. We assessed the immunogenicity of an inactivated H5N1 whole-virion vaccine (A/Vietnam/1194/2004 NIBRG-14, clade 1) formulated with emulsified nanoparticles and investigated whether it can induce cross-clade protecting immunity.
%U http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0012279