%0 Journal Article
%T Study on the Mechanisms of NRK Cells Apoptosis Induced by Cadmium<br>镉诱导大鼠肾细胞凋亡及其机理的研究
%A JIA Guang-le
%A WANG Zhong
%A WU Shao-qiang
%A LIN Xiang-mei
%A HAN Xue-qing
%A LIU Jian
%A MEI Lin
%A ZHANG Min
%A <br>贾广乐
%A 王众
%A 吴绍强
%A 林祥梅
%A 韩雪清
%A 刘建
%A 梅琳
%A 张旻
%J 生态毒理学报
%D 2008
%I 
%X In order to study the death-receptor pathway in NRK cell apoptosis induced by cadmium, different concentrations of cadmium chloride (0, 10, 20, 40, 60mmol·L-1) were added to NRK cell culture medium and cultured for 6h. Apoptosis rate, Caspase-8 activity and expression level of mRNA of Caspase-8 and Fas were detected by flow cytometry, spectrophotometer and RT-PCR, respectively. Results showed that concomitant dose-dependent increases in apoptosis rate, Caspase-8 activity and the expression level of Caspase-8 and Fas mRNA were found, which indicated apoptosis of NRK cells could be induced by cadmium through death-receptor pathway.
%K cadmium
%K NRK cell
%K death-receptor pathway<br>镉
%K NRK细胞
%K 死亡受体途径
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=3FF3ABA7486768130C3FF830376F43B398E0C97F0FF2DD53&cid=BEC1F4700DD66C14D137590A0896A0AD&jid=B98D390DF92C35E6DD1987675E4EE86E&aid=1DB6B904AC841B66E5E5056BA9103456&yid=67289AFF6305E306&vid=38B194292C032A66&iid=38B194292C032A66&sid=DC330B09A33F1455&eid=9F8C5EF901EA1E7E&journal_id=1673-5897&journal_name=生态毒理学报&referenced_num=0&reference_num=14