%0 Journal Article
%T Nuclear Receptor Superfamily and Yeast Two-Hybrid System<br>核受体超家族及其酵母双杂交检测技术
%A LI Jian
%A RAO Kai-feng
%A MA Mei
%A WANG Zi-jian State Key Laboratory of Environmental Aquatic Chemistry
%A Research Center for Eco-Environmental Sciences
%A Chinese Academy of Sciences
%A Beijing College of Water Science
%A Beijing Normal University
%A Beijing
%A <br>李剑
%A 饶凯锋
%A 马梅
%A 王子健
%J 生态毒理学报
%D 2008
%I 
%X More and more attention has been paid to the challenging issue on endocrine disruption induced by environmental pollutants in recent years. There has been a great increase in the amount of researches, which demonstrated that nuclear receptor was important action site of endocrine disruptions. Based on these research results, the members, the structural characteristics, and action models of nuclear receptor superfamily were reviewed. In this review, the newly progress in endocrine disruptions and nuclear receptor superfamily were discussed. The mechanism of yeast two-hybrid system and its usages in the nuclear receptor superfamily and endocrine disruptions were analyzed. It is suggested that the yeast two-hybrid system should be used in the nuclear receptor superfamily study and the recombinant receptor gene yeast can be built and used for study endocrine disrupting effects and mechanism of actions.
%K nuclear receptor superfamily
%K yeast two-hybrid system
%K environmental endocrine disrupting chemical<br>核受体超家族
%K 酵母双杂交
%K 环境内分泌干扰物
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=3FF3ABA7486768130C3FF830376F43B398E0C97F0FF2DD53&cid=BEC1F4700DD66C14D137590A0896A0AD&jid=B98D390DF92C35E6DD1987675E4EE86E&aid=20EBA922806022C69C29F99670444323&yid=67289AFF6305E306&vid=38B194292C032A66&iid=B31275AF3241DB2D&sid=68FF5306A8F9C315&eid=640CCB6E396307A8&journal_id=1673-5897&journal_name=生态毒理学报&referenced_num=2&reference_num=59