%0 Journal Article
%T Potassium Currents in Neurons of Rats Were Reduced by IL-1β in Time Dependent Manner<br>白介素1β时间依赖性地抑制大鼠皮层神经元钾电流
%A 张伟伟
%A 周辰
%A 齐翠
%A 鲍朝飞
%A 景军展
%A 张丽瑶
%A 韩素娥
%J 生物物理学报
%D 2009
%I 
%X Interleukin-1β (IL-1β) is an important porinflammatory cytokine that exert widely biology functions in central nervous system (CNS). Many Studies had reported that the effects of IL-1β were complicated. These effects include both of neuroprotective and neurotoxic effects in different models or conditions. Voltage-gated K+ channels contribute to the excitability of neurons, and regulate shape of action potential. Although both of IL-1β and K+ channels play key roles in injury and disease of brain, so far the relations of them was reported in few studies. In this study, whole cell patch-clamp recording was used to investigate the effects of IL-1β (10 ng/mL) treatment for 8 and 24 hours on voltage-dependent K+ currents of cultured cortical neurons from rats. Base on the properties of the currents, K+ currents were divided into two components, i.e. transient outward potassium current (IA)-dominant IA-like and delayed rectifier potassium current (IK)-dominant IK-like currents. The results showed that both of the K+ currents in cortical neurons were not affected by IL-1β treatment for 8 hours, but significantly inhibited by treatment for 24 hours. Our results suggested that the voltage-gated K+ currents were inhibited by IL-1β treatment in time dependent manner in cortical neurons of rats.
%K Interleukin-1&beta
%K cortical neurons
%K voltage-dependent K+ currents
%K patch-clamp recording<br>白介素1&beta
%K 皮层神经元
%K 电压依赖性钾电流
%K 膜片钳记录
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=E0C9D9BBED813D6674AC13E942EAC86D&aid=E5B72993A71AC65B0E8EB0E3D4D3EB02&yid=DE12191FBD62783C&vid=C5154311167311FE&iid=B31275AF3241DB2D&sid=BFB86B6ED3A99B9D&eid=B941678158018439&journal_id=1000-6737&journal_name=生物物理学报&referenced_num=0&reference_num=0