%0 Journal Article
%T The Study of Liposome Surface Ligand Density on Its Targeting Efficiency in vivo<br>多肽靶向脂质体的表面配体修饰密度及其体内肿瘤靶向效果的研究
%A ZHOU Zhengyuan
%A TANG Hailing
%A XU Yuhong School of Pharmacy
%A Shanghai Jiaotong University
%A Shanghai
%A <br>周正源
%A 唐海玲
%A 徐宇虹
%J 生物物理学报
%D 2010
%I 
%X Liposomes-based anticancer drug delivery system has been developed and widely used in clinical tumor therapy. In addition,active targeting strategies were proposed,in which antibodies or targeting ligands were used to direct the liposomes to further encourage the interaction between drug loaded liposomes and tumors. Obviously,the density and conformation of the targeting ligand on the surface of the liposome have huge effects on its targeting efficiency in vivo. However,there is no last word about their rel...
%K peptide targeting ligand
%K liposome
%K surface density
%K HPLC<br>靶向多肽配体
%K 脂质体
%K 表面密度
%K HPLC
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=E0C9D9BBED813D6674AC13E942EAC86D&aid=FA880E14E0506A8943B995366426D06D&yid=140ECF96957D60B2&vid=96C778EE049EE47D&iid=38B194292C032A66&sid=CEC789B3C68C3BB3&eid=A1266CF37D675CF1&journal_id=1000-6737&journal_name=生物物理学报&referenced_num=0&reference_num=0