%0 Journal Article
%T MODELING STUDY IN THE INTERCALATING COMPLEX ANTICANCER DRUG-ADRIAMYCIN AND DNA<br>抗癌药ADM与DNA嵌插复合物的模型化研究
%A 李光
%A 温元凯
%J 生物物理学报
%D 1990
%I 
%X By means of fast energy mimmization method, three kinds of intercalating models of ADRIAMYCIN-DNA ( 3bp) have been calculated and refined The Pigram-Fuller-Hamilton(PFH) model has been proved theoretically to be the optimum intercalating model. The nonintercalating interaction in PFH modd playing the most important in PFH model playing the most important role in choosing optimum complx has been discussed The affinity of ADRIAMYCIN to DNA sequences depending on the intercalating modes has been illustrated.
%K 抗癌药
%K ADM
%K ADM－DNA
%K 模型化
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=E0C9D9BBED813D6674AC13E942EAC86D&aid=A29F74E1077628AE891125F536D42759&yid=8D39DA2CB9F38FD0&vid=B31275AF3241DB2D&iid=E158A972A605785F&sid=12AD09BCF4A6E651&eid=90075EB19043D533&journal_id=1000-6737&journal_name=生物物理学报&referenced_num=0&reference_num=0