%0 Journal Article
%T Comprehensive Analysis of Propensities of Amino Acids and Nucleotides Usage at Protein-Nucleic Acid Interfaces<br>蛋白质-核酸复合物界面氨基酸与核苷酸偏好性分析
%A WU Jiansheng
%A HU Dong
%A WU Hongtao
%A XIE Jianming
%A SUN Xiao School of Geography
%A Biological Information
%A Nanjing University of Posts
%A Telecommunications
%A Nanjing
%A China
%A State Key Laboratory of Bioelectronics
%A School of Biological Science
%A Medical Engineering
%A Southeast University
%A Nanjing
%A <br>吴建盛
%A 胡栋
%A 伍洪涛
%A 谢建明
%A 孙啸
%J 生物物理学报
%D 2010
%I 
%X The mechanism of protein-nucleic acid interaction is still not very clear, especially that of protein-RNA interaction. Therefore, with the increase of available protein-nucleic acid complex structures in the protein data bank database, the authors have collected all the structures and then analyzed the rules controlling the recognition of residues by nucleotides using classical statistical methods. The results show that: 1) The number of nucleotide-binding residues presents significant differences among each kind of protein-nucleic acid complex structures with different functions; 2) The basic amino acids are the most popular in both protein-DNA and protein-RNA interactions; 3) The size and orientation of the polarity of amino acids play important roles in determining whether they are combined with RNA molecules, and the steric hindrances formed by the side chain of amino acids appear to influence the course of recognizing residues by nucleotides; 4) Specificity of amino acid usage for binding residues reduces while the threshold in defining of nucleotide-binding residues increases, however, there is no change in types of amino acid regardless of popular or unpopular ones.
%K Protein - nucleic acid interfaces
%K Binding residues
%K Binding propensity
%K Polarity of amino acids<br>蛋白质-核酸复合物界面
%K 结合残基
%K 结合偏好性
%K 氨基酸极性
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=E0C9D9BBED813D6674AC13E942EAC86D&aid=6CFECFBA259CA9FDA71D25B1D8DAB06A&yid=140ECF96957D60B2&vid=96C778EE049EE47D&iid=38B194292C032A66&sid=D9AE183D3F5C3C75&eid=5B5B75F4854B8331&journal_id=1000-6737&journal_name=生物物理学报&referenced_num=0&reference_num=0