%0 Journal Article
%T A MOLECULAR DYNAMICS STUDY ON DES-HEPTAPEPTIDE INSULIN<br>去七肽胰岛素的分子动力学研究
%A 王化军
%A 陈润生
%A 倪向善
%A 石秀凡
%J 生物物理学报
%D 1986
%I 
%X A molecular dynamics study on des-hcptapeptide insulin conformation has been carried out. The energy of the conformation of insulin has been minimized using molecular dynamics method, the cnergy-refined conformation of insulin is obtained. Then the last seven residues in the C-terminal of the B-chain (B24-B30) are removed, a molecular dynamics simulation has been carried out. The equilibrium conformation and r. m. s. fluctuation of des-heptapeptide insulin (DHPI) are obtained. The r.m.s. deviation of all atoms between the X-ray-structure and energy-refined conformation of insulin is 0.1 A. The r.m.s. deviation of C atoms between the obtained DHPI conformation and the energy-refined conformation of insulin is 1.8 A. The largest change happened in A8-A10, A18-A21, B1-B4, B18-B23.
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=E0C9D9BBED813D6674AC13E942EAC86D&aid=CF4550BBDDA03234DCEB92B2C9E85ACE&yid=4E65715CCF57055A&vid=0B39A22176CE99FB&iid=E158A972A605785F&sid=A22854835F81B3F8&eid=396DD691E964F390&journal_id=1000-6737&journal_name=生物物理学报&referenced_num=0&reference_num=0