%0 Journal Article
%T Prolong sub-chronic exposed to Microcystis cell extract results in oxidative stress in mice liver<br>微囊藻细胞抽提物亚慢性暴露导致小鼠肝脏氧化应激
%A 张榜军
%A 李效宇
%J 水生生物学报
%D 2009
%I 
%X Recent studies have indicated that oxidative damage is involved in the toxicity of microcystins in animals. In the present study, the induction of oxidative stress by Microcystis cell extract in the liver of mice after prolonged exposure to cell extracts of Microcystis aeruginosa was investigated. The extracts were administered by intraperitoneal injection to Kunming mice at a daily dose of 3.3 μg microcystins/kg for 28 days. Toxin-induced damage of the liver was found by histological observation. Determination of lipid peroxidation demonstrated a significant increase in malondiadehyde in the toxin-treated mice compared to the control group. The activities of anti-oxidant enzymes (superoxide dismutase, catalase, and glutathione peroxidase) and the detoxification enzyme glutathione S-transferase in the liver of microcystin-treated mice were significantly increased compared to the control. These results showed that prolonged exposure to Microcystis cell extract led to oxidative stress in mouse liver, and oxidative stress might play an important role in the pathogenesis of microcystin-induced toxicity
%K Microcystis cell extracts
%K Antioxidant system
%K Lipid peroxidation
%K Oxidative stress
%K Mice<br>微囊藻细胞抽提物
%K 抗氧化系统
%K 脂质过氧化
%K 氧化应激
%K 小鼠
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=256651267D5D2E4520A7707D05E98747&aid=54E4FAA4CCA8D0FC01EC165841295B91&yid=DE12191FBD62783C&vid=27746BCEEE58E9DC&iid=B31275AF3241DB2D&sid=2B25C5E62F83A049&journal_id=1000-3207&journal_name=水生生物学报&referenced_num=0&reference_num=44