%0 Journal Article
%T Microcalorimetric Studies of the Action on Four Organic Acids in Radix isatidis on the Growth of Microorganisms<br>微量热法研究板蓝根中四种有机酸对微生物生长代谢的影响
%A Weijun Kong
%A Yanling Zhao
%A Limei Shan
%A Xiaohe Xiao
%A Weiying Guo
%A <br>孔维军
%A 赵艳玲
%A 山丽梅
%A 肖小河
%A 郭伟英
%J 生物工程学报
%D 2008
%I 
%X The actions of four organic acids in Radix isatidis, a traditional Chinese medicinal (TCM) herb, on Escherichia coli, Staphylococcus aureus and Shigella dysenteriae growth were investigated by microcalorimetry. The four organic acids were syringic acid, 2-amino-benzoic acid, salicylic acid and benzoic acid. The power-time curves of Escherichia coli, Staphylococcus aureus and Shigella dysenteriae growth with and without organic acids were acquired, meanwhile the extent and duration of inhibitory effects on the metabolism were evaluated by growth rate constants (k1, k2), maximum heat-output power (Pm) and peak time (tm). The inhibitory activity varied with different drugs. The sequences of anti-microbial activity of the four organic acids on Escherichia coli, Staphylococcus aureus and Shigella dysenteriae were all: syringic acid > 2-amino-benzoic acid > salicylic acid > benzoic acid. And benzoic acid promoted the growth of Staphylococcus aureus and Shigella dysenteriae. This study provides a basis for the further study on Radix Isatidis.
%K Radix isatidis
%K microcalorimetry
%K organic acids
%K microorganism
%K anti-microbial activity<br>板蓝根
%K 微量热法
%K 有机酸
%K 微生物
%K 抗微生物活性
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=A66E90C274451689E69F6F0291467824&aid=1FD752E4F675DE262B11EA0E3948AFB6&yid=67289AFF6305E306&vid=B91E8C6D6FE990DB&iid=E158A972A605785F&sid=6C62BFE34266FA92&eid=7C13E30F5EDBE7AB&journal_id=1000-3061&journal_name=生物工程学报&referenced_num=0&reference_num=15