%0 Journal Article
%T EFFECTS OF CHOLESTEROL ON THE LIPID BILAYER STRUCTUREBY SAXS AND STM<br>胆固醇对脂双层结构影响的SAXS和STM研究
%A SUN Run-guang
%A ZHANG Jing
%A QI Hao
%A WANG Yong-chang
%A <br>孙润广
%A 张静
%A 齐浩
%A 王永昌
%J 生物物理学报
%D 2001
%I 
%X The effect of cholesterol on the phospholipid bilayer structure and polymorphism of liposomes have been investigated by method of the small angle X-ray diffraction (SAXS) and by the technique of scanning tunneling microscope (STM). The experiments proved that the STM images of the two-dimensional point array of the phospholipid molecules formed on graphite and that the STM images of the two-dimensional corrugated array of the liposomes of phospholipid and cholesterol formed on graphite. By using small angle X-ray diffraction we demonstrate the presence of lamellar phase in the DPPC liposomes. The cholesterol induces spontaneous formation of a complex lamellar phase in the DPPC-cholesterol liposomes and promotes formation of lamellar and cubic phase in the DPPE-cholesterol liposomes. The presence of cholesterol allowed the system to organize in cubic and hexagonal phase in DPPC-DPPE-cholesterol liposomes.
%K Cholesterol
%K Liposomes
%K Small angle X-ray diffraction
%K Scanned tunneling microscope<br>胆固醇
%K 脂质体
%K 小角X射线散射
%K 扫描隧道显微镜
%K 生物膜
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=E0C9D9BBED813D6674AC13E942EAC86D&aid=F979ACB923E014D5&yid=14E7EF987E4155E6&vid=BCA2697F357F2001&iid=CA4FD0336C81A37A&sid=8E6AB9C3EBAAE921&eid=9FFCC7AF50CAEBF7&journal_id=1000-6737&journal_name=生物物理学报&referenced_num=7&reference_num=15