%0 Journal Article
%T Conservative analysis of type III secretion system chaperone protein sequence and prediction of new chaperone<br>致病菌III型分泌系统分子伴侣序列保守性分析及新伴侣的预测
%A WANG Li
%A WANG Yu-min
%A WANG Qiong
%A GUO Zhi-yun
%A LIANG Long
%A HUANG Pei-tang
%A <br>汪莉
%A 王玉民
%A 汪琼
%A 郭志云
%A 梁龙
%A 黄培堂
%J 生物物理学报
%D 2005
%I 
%X Many Gram negative pathogen utilize type III secretion system (TTSS) to inject toxins into the cytosol of eukaryotic cell. Some effector proteins (toxins) are secreted by their cognate chaperones through the TTSS. Previous studies indicated that there is little amino-acid sequence similarity among these chaperones. However, by bioinformatics methods, we find that many chaperones have more than one homologous chaperones, and two known motifs and three newly identified motifs exist widely in these chaperones which indicate that there must exist some conservative sites in TTSS chaperones protein sequences. Base on above, we predicted 27 new prossible TTSS chaperones.
%K Ⅲ型分泌系统
%K 分子伴侣
%K 毒力因子
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=E0C9D9BBED813D6674AC13E942EAC86D&aid=F03CD247EA15EC34&yid=2DD7160C83D0ACED&vid=659D3B06EBF534A7&iid=0B39A22176CE99FB&sid=89F76E117E9BDB76&eid=A63576421B012172&journal_id=1000-6737&journal_name=生物物理学报&referenced_num=3&reference_num=20