%0 Journal Article
%T Chimeric Fibrinolytic Enzymes: Progress And Prospective<br>嵌合体纤溶酶的研究进展
%A XIAO Rong
%A ZHAO Jing
%A LI Qing-Wei
%A <br>肖蓉
%A 赵静
%A 李庆伟
%J 生物物理学报
%D 2005
%I 
%X Chimeric fibrinolytic enzymes are the chimeric protein formed by fibrinolytic enzymes combine with other functional poly peptides which contain zymogen domain, have activity of antithrombin and antiplatelet aggregation fragments and recognizing fibrin sequences by using gene recombinant technique or chemical conjugation methods. The chimeric fibrinolytic enzymes not only conserve the biological activities of each component to enhance the efficiency of dissolving blood clotting in clinical application, but also supplement the deficiencies of some thrombolytic medicines. Therefore, chimeric fibrinolytic enzymes are becoming the focuses of current study in thrombusis drugs.
%K Chimeric
%K Fibrinolytic enzymes
%K Zymogen chimeric
%K Antithrombin activity
%K Antipletelet aggregation activity
%K Peptides which specially recognize fibrin
%K Thrombusis<br>嵌合体
%K 纤溶酶
%K 酶原型嵌合体
%K 抗凝血酶活性
%K 抗血小板聚集活性
%K 特异识别纤维蛋白多肽
%K 溶栓
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=E0C9D9BBED813D6674AC13E942EAC86D&aid=E783EF7F0536371A&yid=2DD7160C83D0ACED&vid=659D3B06EBF534A7&iid=0B39A22176CE99FB&sid=869807E2D7BED9EC&eid=BB0EA31DB1B01173&journal_id=1000-6737&journal_name=生物物理学报&referenced_num=0&reference_num=13