%0 Journal Article
%T Optimization of high-cell-density fermentation process for S-adenosyl-L-methionine production<br>S-腺苷-L-蛋氨酸高密度发酵工艺优化
%A Jiepeng Wang
%A Jinjun Han
%A Xiaonan Li
%A Peiyi Liu
%A Tianwei Tan
%A <br>王杰鹏
%A 韩晋军
%A 李晓楠
%A 刘沛溢
%A 谭天伟
%J 生物工程学报
%D 2009
%I 
%X Poor stability existed in the anaphase of the high-cell-density fermentation of Saccharomyces crevisiae for S-adenosyl-L-methionine (SAM) production in 5 L fermentor. To improve the fermentation stability,we studied the addition of diammonium hydrogen phosphate,sodium glutamate and adenosine disodium triphosphate into glucose feeding solution. Study of four fed-batch cultures showed that,after 34 h fermentation,when dry cell weight reached 100 g/L,the addition of 50 g pre-L-methionine and glucose feeding wi...
%K S-adenosyl-L-methionine (SAM)
%K ATP
%K high-cell-density fermentation
%K L-methionine<br>S-腺苷-L-蛋氨酸
%K ATP
%K 高密度发酵
%K L-蛋氨酸
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=A66E90C274451689E69F6F0291467824&aid=2F6DBD4F584A4B93445148CA6E535871&yid=DE12191FBD62783C&vid=C5154311167311FE&iid=E158A972A605785F&sid=FF58680609C9D068&eid=323E8A365B085E0B&journal_id=1000-3061&journal_name=生物工程学报&referenced_num=1&reference_num=14