%0 Journal Article
%T DNA-EGS1386 in cells induced RNase P inhibits the expression of human cytomegalovirus UL49 gene<br>DNA-EGS1386胞内诱导核酶P抑制人巨细胞病毒UL49基因的表达
%A Yanwei Cui
%A Zhifeng Zeng
%A Hongjian Li
%A Yueqin Li
%A Qi Zhou
%A Dan Yang
%A Yi Zou
%A Guang Yang
%A Tianhong Zhou
%A <br>崔延伟
%A 曾志锋
%A 李弘剑
%A 李月琴
%A 周琪
%A 杨丹
%A 邹奕
%A 杨光
%A 周天鸿
%J 生物工程学报
%D 2009
%I 
%X External Guide Sequences(EGSs) represents a novel nucleic acid based gene interference approach to modulate gene expression.They are oligonucleotides that consist of a sequence complementary to a target mRNA and recruit intracellular RNase P for specific degradation of the target RNA.DNA-based EGS1386 with a size of 12 nt was chemically synthesized to target the mRNA coding for the UL49 gene of human cytomegalovirus(HCMV).The DNA-based EGS1386 molecule efficiently directed human RNase P to cleave the target...
%K miniEGSs
%K gene silencing
%K UL49 gene
%K RNase P<br>短的EGS
%K 基因沉默
%K UL49基因
%K 核酶P
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=A66E90C274451689E69F6F0291467824&aid=5EC22A526D953E748203B32C17DB4218&yid=DE12191FBD62783C&vid=C5154311167311FE&iid=708DD6B15D2464E8&sid=721F8E311AAA0176&eid=EB4751E019AF0441&journal_id=1000-3061&journal_name=生物工程学报&referenced_num=0&reference_num=19