%0 Journal Article
%T Predict siRNA Activity Based on Back-Propagation Neural Network<br>基于BP神经网络的siRNA活性预测
%A LI Jian-long
%A WANG Zheng-zhi
%A <br>李建龙
%A 王正志
%J 生物物理学报
%D 2006
%I 
%X RNAi is a phenomenon of gene silence induced by double-stranded RNA(dsRNA) that is homologous to target gene.RNAi can be used to identify the function of gene or knock down the targeted gene.In RNAi technology,19 bp double-stranded short interfering RNAs with characteristic 3'overhangs are usually used.siRNA activity often changes much due to different site choosing of the targeted mRNA,the causes are many and nonlinear.In this article the authors tried to find the motif features that affect siRNA activity and abstracted them from some published data of experiments,then they built a database,BP NN,and trained based on the database.The trained BP NN can be used to predict siRNA activity.
%K RNAi
%K dsRNA
%K Activity
%K Back-propagation neural network<br>RNA干扰
%K 双链RNA
%K 活性
%K BP神经网络
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=E0C9D9BBED813D6674AC13E942EAC86D&aid=9CEDDEF00FEB5EE4&yid=37904DC365DD7266&vid=BC12EA701C895178&iid=B31275AF3241DB2D&sid=9BA67A0B76A3DBA8&eid=E57FE519484CFB70&journal_id=1000-6737&journal_name=生物物理学报&referenced_num=0&reference_num=12