%0 Journal Article
%T A DYNAMICAL MODEL DESCRIBING T CELL ACTIVATION<br>T细胞活化的动力学模型
%A ZHANG Wei
%A YANG Xian-qing
%A QI An-shen
%A <br>张伟
%A 杨先清
%A 漆安慎
%J 生物物理学报
%D 2001
%I 
%X The function of DIGs (detergent-insoluble glycolipid-enriched domains)in the immune response has become a focus of discussion in immunology. A theoretical model is proposed in this paper which accounts for the interaction of TCR with its ligand to confirm the importance of the immunological synapse and the mechanism of sufficient PTKs recruitment in T cell activation. This model relies on a serial triggering model. The mechanism of interactions between the antigen-specific TCRs and their antigentic ligands is explored. The function of the co-receptors during the formation of the immuological synapse and the recognition of the antigen by the TCR is investigated.It is theoretically studied that subtle changes of ligands would influence the outcomes of T cell receptor ligation. Using this model, it is shown that the access affinity of TCR with ligand, the ligand dissociation rate from TCR-pep complex and the co-receptors play important roles in determining the outcomes of T cell activation. With respect to the certain ligand and certain T cell clone, the dissociation rate determines the ligand agonist or antagonist. In addition, through the interaction of CD4/CD8 with TCR-MHC/pep, the co-receptors change the dissociation rate of the complexes and consequently affect the outcomes of the immune response. The model proved that the oligomer of TCR-pep/MHC complexes in the DIGs is important while the sufficient PTKs within DIGs assure the signal transduction.
%K Affinity
%K TCR
%K DIGs
%K PTKs<br>亲和力
%K TCR
%K DIGs
%K PTKs
%K T细胞活化
%K 动力学模型
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=E0C9D9BBED813D6674AC13E942EAC86D&aid=5146211D02170D21&yid=14E7EF987E4155E6&vid=BCA2697F357F2001&iid=38B194292C032A66&sid=78BF76CF5B7CB0F2&eid=522844664D9E629A&journal_id=1000-6737&journal_name=生物物理学报&referenced_num=1&reference_num=19