%0 Journal Article
%T Construction of Engineered Escherichia coli for Aerobic Succinate Production<br>好氧发酵生产琥珀酸工程菌株的构建
%A Zhen Kang
%A Yanping Geng
%A Yuanyuan Zhang
%A Qingsheng Qi
%A <br>康振
%A 耿艳平
%A 张园园
%A 祁庆生
%J 生物工程学报
%D 2008
%I 
%X Based on carbon metabolic pathway analysis of Escherichia coli MG1655, an aerobic succinate fermentation platform was constructed by knocking out five genes (ptsG, poxB, pta, iclR and sdhA), which was named E. coli QZ1111. Flask cultivation results showed that E. coli QZ1111 could accumulate succinate with a concentration of 26.4 g/L under aerobic conditions. The byproduct acetate was only 2.3 g/L. The production ratio of succinate and acetate reached 11.5:1.
%K Escherichia coli
%K succinic acid
%K metabolic engineering<br>大肠杆菌
%K 琥珀酸
%K 代谢工程
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=A66E90C274451689E69F6F0291467824&aid=6E99FB71CFAF92DFA726CA34311BC51F&yid=67289AFF6305E306&vid=B91E8C6D6FE990DB&iid=59906B3B2830C2C5&sid=6756FAD7BC937C79&eid=FA7F82B640E17733&journal_id=1000-3061&journal_name=生物工程学报&referenced_num=1&reference_num=14