%0 Journal Article
%T Chemical Cross-linking and Mass Spectrometry for Investigation of Protein Complex Structures and Protein-protein Interactions<br>蛋白质复合体及蛋白质相互作用研究新策略—化学交联结合质谱分析法
%A 王晓东
%A 李智立
%J 生物物理学报
%D 2009
%I 
%X Chemical cross-linking combined with mass spectrometry has been being widely used in the research of protein complex structures and protein-protein interactions, and many studies indicated that it is a novel tool to probe the structural modeling of protein complexes and protein-protein interactions. Different cross-linking agents with different chemical activities, Bottom-up and Top-down strategies, and the applications are reviewed. It is believed that the development of cross-linking and mass spectrometric technologies will greatly promote the research of biomacromolecular complex structures and protein-protein interactions.
%K Chemical cross-linking
%K Mass spectrometry
%K Protein complexes
%K Protein-protien<br>化学交联
%K 质谱法
%K 蛋白质复合体
%K 蛋白质相互作用
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=E0C9D9BBED813D6674AC13E942EAC86D&aid=F06DD6A921B56B689BEB9E15F01CC40E&yid=DE12191FBD62783C&vid=C5154311167311FE&iid=38B194292C032A66&sid=0B4F496D54044D86&eid=ED01F5AE50BE09C0&journal_id=1000-6737&journal_name=生物物理学报&referenced_num=1&reference_num=0