%0 Journal Article
%T Impact of different adjuvant on immunogenicity of the HBV particle vaccine containing the S + PreS1 fusion antigen in Balb/C mice<br>不同佐剂对含S+PreS1融合抗原的乙型肝炎病毒颗粒疫苗免疫原性的影响
%A Hong Chen
%A Yao Deng
%A Wenjie Tan
%A Wen Wang
%A Xiao Yin
%A Jie Guan
%A Wenling Wang
%A Li Ruan
%A <br>陈红
%A 邓瑶
%A 谭文杰
%A 王文
%A 殷霄
%A 管洁
%A 王文玲
%A 阮力
%J 生物工程学报
%D 2010
%I 
%X We previous reported the development of novel hepatitis B virus(HBV) vaccine containing the surface antigen(S) plus PreS1 fusion derived from Chinese hamster ovary (CHO) cells system. In this study, we analyzed the impact of different adjuvants on immunogenicity of the HBV particle vaccine in Balb/C mice, including alum alone, CpG oligodeoxynucleotides (CpG-ODN) alone and CpG-ODN in combination with alum adjuvant. We first detected the antigen specific humoral response in mice, including total IgG antibody ...
%K hepatitis B virus (HBV)
%K viral particles
%K vaccine
%K CpG-ODN<br>乙型肝炎病毒
%K 病毒颗粒
%K 疫苗
%K CpG佐剂
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=A66E90C274451689E69F6F0291467824&aid=A31C3921A7D440BC8AA8ED8FB30B3C38&yid=140ECF96957D60B2&vid=96C778EE049EE47D&iid=CA4FD0336C81A37A&sid=67969BA850333433&eid=46CB27789995047D&journal_id=1000-3061&journal_name=生物工程学报&referenced_num=1&reference_num=10