%0 Journal Article
%T Capsid assembly and DNA encapsidation of adeno-associated virus<br>腺相关病毒的衣壳装配和DNA衣壳化机制
%A Qizhao Wang
%A Yinghui Lu
%A Zhaofa Li
%A Yong Diao
%A Rui'an Xu
%A <br>王启钊
%A 吕颖慧
%A 李招发
%A 刁勇
%A 许瑞安
%J 生物工程学报
%D 2011
%I 
%X Recombinant adeno-associated viral vectors (rAAV) have been widely used as gene therapy vectors in clinical trials. Here, we reviewed the genomic structures and replication mechanisms of wt-AAV. Then, the assembly of capsid and the encapsidation of genomic DNA, two major events during AAV pakaging, was discussed in detail. Although the overall pattern of virus assembly and encapsidation is known, the molecular mechanisms and the structure-function relationship involved in these processes are not well understood. Further elucidatation of these processes may improve the production technology of rAAV and develop gene drug based on rAAV.
%K adeno-assoicated virus
%K assembly
%K encapsidation
%K gene therapy<br>腺相关病毒，装配，衣壳化，基因治疗
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=A66E90C274451689E69F6F0291467824&aid=83EAF5C9812C62FB57912045C3EBB7AD&yid=9377ED8094509821&vid=DB817633AA4F79B9&iid=E158A972A605785F&sid=20ADD38F841C6A4B&eid=E49BED2EA9A8956B&journal_id=1000-3061&journal_name=生物工程学报&referenced_num=0&reference_num=36