%0 Journal Article
%T RNA Secondary Structure Prediction Based on Support Vector Machine Classification<br>基于支持向量机分类的RNA共同二级结构预测
%A Yingjie Zhao
%A Zhengzhi Wang
%A <br>赵英杰
%A 王正志
%J 生物工程学报
%D 2008
%I 
%X The comparative sequence analysis is the most reliable method for RNA secondary structure prediction, and many algorithms based on it have been developed in last several decades. This paper considers RNA structure prediction as a 2-classes classification problem: given a sequence alignment, to decide whether or not two columns of alignment form a base pair. We employed Support Vector Machine(SVM) to predict potential paired sites, and selected co-variation information, thermodynamic information and the fraction of complementary bases as feature vectors. Considering the effect of sequence similarity upon co-variation score, we introduced a similarity weight factor, which could adjust the contribution of co-variation and thermodynamic information toward prediction according to sequence similarity. The test on 49 Rfam-seed alignments showed the effectiveness of our method, and the accuracy was better than many similar algorithms. Furthermore, this method could predict simple pseudoknot.
%K comparative sequences analysis
%K RNA secondary structure
%K support vector machine
%K similarity weight factor<br>比较序列分析
%K RNA二级结构
%K 支持向量机
%K 相似性影响因子
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=A66E90C274451689E69F6F0291467824&aid=488F40055EEE283847A922FA01B33101&yid=67289AFF6305E306&vid=B91E8C6D6FE990DB&iid=DF92D298D3FF1E6E&sid=D932AD0F8FDA3032&eid=D5BEB939E141E547&journal_id=1000-3061&journal_name=生物工程学报&referenced_num=0&reference_num=51