%0 Journal Article
%T Anti-angiogenic activities of Lj-RGD3 toxin protein from Lampetra japonica and its mutation protein Lj-112 without RGD motifs<br>日本七鳃鳗Arg-Gly-Asp毒素蛋白Lj-RGD3野生型与RGD全缺失突变体Lj-112的抗血管新生作用
%A 王继红
%A 张亚前
%A 吕莉
%A 刘欣
%A 李庆伟
%J 生物工程学报
%D 2011
%I 
%X Arg-Gly-Asp(RGD)-toxin protein Lj-RGD3 of Lampetra japonica shares homologous with a Histidine-rich glycoprotein(HRG),and both RGD-toxin protein and HRG have antiangiogenic activities with different targets.To study the relationship between the function and the structure of Lj-RGD3,we studied the anti-angiogenic characteristics of both Lj-RGD3 and the mutation named Lj-112 of which three RGD motifs of Lj-RGD3 were deleted.We synthesized the gene of Lj-112,constructed it to the plasmid pET23b,and expressed t...
%K Lampetra japonica
%K RGD-toxin proteins
%K histidine-rich glycoprotein (HRG)
%K mutation
%K angiogenesis<br>日本七鳃鳗，RGD毒素蛋白，富含组氨酸糖蛋白，突变体，血管新生
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=A66E90C274451689E69F6F0291467824&aid=F437B1BF01E7F486F3626A4396961CBF&yid=9377ED8094509821&vid=DB817633AA4F79B9&iid=F3090AE9B60B7ED1&sid=1658FDEF8AE04907&eid=A67C4D140E145357&journal_id=1000-3061&journal_name=生物工程学报&referenced_num=0&reference_num=22