%0 Journal Article
%T Transplantation of atrial natriuretic peptide-expressing fibroblasts reduces blood pressure and increases urine volume in spontaneously hypertensive rats<br>心钠素表达细胞移植降低高血压大鼠的血压和增加其尿量
%A Tao Li
%A Hongyan Liang
%A Jinzhi Lu
%A Weijing Chen
%A Shengdong Lu
%A <br>李涛
%A 梁红雁
%A 路金芝
%A 陈伟京
%A 卢圣栋
%J 生物工程学报
%D 2010
%I 
%X To investigate the potential of gene therapy for the treatment of chronic diseases such as hypertension, chronic heart failure, and chronic renal failure, we established the neonatal rat fibroblast line engineered to secrete the mutant human atrial natriuretic peptide (mhANP), and then transplanted the cell line into young spontaneously hypertensive rats (SHR) subcutaneously. We found that a single transplantation of the cell line caused an obvious rise in the concentration of mhANP in serum 7 d after trans...
%K atrial natriuretic factor
%K gene therapy
%K retroviral vector
%K hypertension
%K spontaneously hypertensive rat<br>心钠素，基因治疗，逆转录病毒载体，高血压，自发性高血压大鼠
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=A66E90C274451689E69F6F0291467824&aid=BA3D12E2416879E2DA83AB76AB4525A1&yid=140ECF96957D60B2&vid=96C778EE049EE47D&iid=94C357A881DFC066&sid=5DD21DF25EF52D4A&eid=421C41B8FD4D3EBA&journal_id=1000-3061&journal_name=生物工程学报&referenced_num=0&reference_num=0