%0 Journal Article
%T Progress in production of arachidonic acid by Mortierella alpina and genetic modification<br>高山被孢霉产花生四烯酸及其遗传改造的研究进展
%A Leilei Cong
%A Chao Peng
%A Xiaojun Ji
%A Zhiyong Li
%A Jiangying You
%A Jinmiao Lu
%A He Huang
%A <br>丛蕾蕾
%A 彭超
%A 纪晓俊
%A 黎志勇
%A 尤江英
%A 路金淼
%A 黄和
%J 生物工程学报
%D 2010
%I 
%X Arachidonic acid, as an important polyunsaturated fatty acid, is identified as potential food additives or pharmaceuticals for their biological activities. In recent years, arachidonic acid production by Mortierella alpina is becoming a research highlight. The prophase relevant researches focused on the mutagenic breeding and fermentation optimization. With the depth of investigation, the advancement concerning pathway for the biosynthesis of arachidonic acid in Mortierella alpina has been made. In this review, we summarized the prophase work briefly. Mainly, we discussed the biosynthesis pathway of arachidonic acid, the key enzymes, the construction of transformation system and the genetic modification. In addition, the prospect of microorganism arachidonic acid production is put forward.
%K arachidonic acid
%K Mortierella alpina
%K key enzymes
%K transformation system
%K genetic modification<br>花生四烯酸，高山被孢霉，关键酶，遗传操作系统，遗传改造
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=A66E90C274451689E69F6F0291467824&aid=B3EDB30047F786CA975A6A6F898B627A&yid=140ECF96957D60B2&vid=96C778EE049EE47D&iid=9CF7A0430CBB2DFD&sid=880C4253794026AD&eid=5C10CB62DEB8898B&journal_id=1000-3061&journal_name=生物工程学报&referenced_num=0&reference_num=0