%0 Journal Article
%T Immune activity of heat shock protein gp96 and its application in active immunotherapy for tumor and infectious diseases<br>热激蛋白gp96免疫学功能及在主动免疫治疗肿瘤和传染病中的应用
%A Yaxing Xu
%A Saifeng Wang
%A Xiaojun Zhang
%A Songdong Meng
%A <br>徐亚星
%A 王赛锋
%A 张小俊
%A 孟颂东
%J 生物工程学报
%D 2012
%I 
%X Heat-shock protein gp96 associates with antigenic peptides derived from tumor and virus. Exogenous gp96-peptide complexes are taken up by antigen-presenting cells through interaction with its receptor CD91 on the cell surface, and cross-present antigenic peptides to MHC class I molecules by a peptide relay line in the endoplasmic reticulum for specific T-cell activation. Meanwhile, gp96 has been shown to initiate innate immune responses through interaction with toll-like receptor 2 and toll-like receptor 4. Recent studies have shown a gp96-mediated immune balance between CTL and Tregs. With the further understanding of counteracting immunosuppressive mechanisms in gp96-induced cellular immune responses, and establishment of high level production of recombinant gp96 by the yeast, gp96 appears to be a promising candidate for designing effective therapeutic vaccines against tumor and infectious diseases.
%K gp96
%K T cell
%K regulatory T cell (Treg)
%K tumor
%K infectious diseases<br>gp96，T细胞，调节性T细胞，肿瘤，传染病
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=A66E90C274451689E69F6F0291467824&aid=59356BAC9D302B108E7FA70C681FAED5&yid=99E9153A83D4CB11&vid=D3E34374A0D77D7F&iid=38B194292C032A66&sid=4D7D059FFBF006B9&eid=4FE459D71E3BF8EB&journal_id=1000-3061&journal_name=生物工程学报&referenced_num=0&reference_num=0