%0 Journal Article
%T Induced Pluripotent Stem Cells Generated from Reprogramming Differentiated Cells by Defined Factors<br>分化细胞经特定因子诱导重编程为多能干细胞
%A Xiaoyu Xi
%A Jianxin Chu
%A Xuejin Chen
%A <br>夏小雨
%A 褚建新
%A 陈学进
%J 生物工程学报
%D 2008
%I 
%X Embryonic stem cell is promising for regenerative medicine. However, its application is hampered by the utilization of eggs in most established methods. Recently, a new pluripotent stem cell establishing method was reported that, mouse and human differentiated cells could be induced reprogrammed into a pluripotent state by expressing exogenetic stem factors such as Oct4, Sox2, et al, through retroviral transduction. This approach avoiding egg use is a great breakthrough not only in stem cell technology but also present theory hypothesis of reprogramming. Here these works were reviewed in this article. Both the mechanism of induced reprogramming and the prospects of induced pluripotent stem cells were discussed.
%K pluripotent stem cell
%K stem cell factor
%K induced reprogramming
%K induced pluripotent stem cells (iPS)
%K retroviral transduction system<br>多能干细胞
%K 干细胞因子
%K 诱导重编程
%K 诱导多能干细胞系
%K 反转录病毒转导系统
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=A66E90C274451689E69F6F0291467824&aid=61E509EA15FA85F358B52A7266DB935C&yid=67289AFF6305E306&vid=B91E8C6D6FE990DB&iid=DF92D298D3FF1E6E&sid=F88EF6DD822B0FF5&eid=FB318F788ECEF1B2&journal_id=1000-3061&journal_name=生物工程学报&referenced_num=0&reference_num=37