%0 Journal Article
%T Advances in Sterol 14a-Demethylase (CYP51)<br>甾醇14a-去甲基化酶(CYP51)的研究进展
%A Jiaoyan Yang
%A Mingjun Liao
%A Shao Yang
%A <br>杨娇艳
%A 廖明军
%A 杨劭
%J 生物工程学报
%D 2008
%I 
%X Sterol 14a-demethylase (CYP51), the most widely distributed member of the P450 superfamily, is the key enzyme in sterol biosynthesis pathway. CYP51 is not only an important model for fundamental P450 structure/function studies, but also an important target protein of cholesterol-lowering agents, antifungal drugs and herbicides. This article reviewed the research advances in CYP51 at various aspects, including sequence characteristics, physiological roles, catalytic properties in vitro, protein structure, structure-function relationships and inhibition of CYP51. The problems remained in current research and designations of CYP51 inhibitors are also discussed.
%K CYP51<br>14α-去甲基化酶
%K 功能
%K 结构
%K 抑制
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=A66E90C274451689E69F6F0291467824&aid=2F5ECEA471C95A43DBA74A364D9ADDF6&yid=67289AFF6305E306&vid=B91E8C6D6FE990DB&iid=F3090AE9B60B7ED1&sid=B219870B99929345&eid=57133673016E56C3&journal_id=1000-3061&journal_name=生物工程学报&referenced_num=0&reference_num=38