%0 Journal Article
%T Advances in efficacy and security of expanded mesenchymal stem cells in vitro<br>体外扩增间充质干细胞功能有效性与移植安全性评价研究进展
%A Jing Liu
%A Lin Song
%A Wei Zou
%A Dong Zhuge
%A Zhanfeng Cui
%A <br>刘晶
%A 宋琳
%A 邹伟
%A 诸葛栋
%A 崔占峰
%J 生物工程学报
%D 2010
%I 
%X The multipotent differentiation and immunosuppression capability of mesenchymal stem cells (MSCs) make it attractive source for stem cell therapy to treat serious diseases, including neural system diseases and immune disorders. For large scale clinical applications, MSCs have to be expanded to produce sufficient quantity for multiple treatments. While conventional passaging is not appropriate for such a task, bioreactor can be used to expand MSCs more efficiently. Yet the efficacy and biosafety of expanded MSCs must be properly assessed before the expanded MSCs can be implanted. This review presented state-of-the-art in expanding MSCs focusing on the progress on the assessment of the efficacy and biosafety of in vitro expanded MSCs. Current obstacles were discussed and future research directions were outlined.
%K mesenchymal stem cells
%K expansion
%K efficacy
%K security<br>间充质干细胞，扩增，有效性，安全性
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=A66E90C274451689E69F6F0291467824&aid=C7EE227710C89E4D1963518BBBB988BE&yid=140ECF96957D60B2&vid=96C778EE049EE47D&iid=59906B3B2830C2C5&sid=3429B4C547F01F4E&eid=D9BD5E184C6E559D&journal_id=1000-3061&journal_name=生物工程学报&referenced_num=0&reference_num=0